EWRR 2023

42nd European Workshop for Rheumatology Research March 9-11, 2023 Dublin, Ireland

Registration Opens - 08 December 2022
Registration Closes - 13 January 2023
EULAR Bursaries Will Be Awarded To Young Investigators. To Apply Tick Box In Abstract Submission Site

Scientific Program

EWRR 2023 Program Booklet

Outline of Sessions

Thursday 9th March 2023

13.30- 15.30EULAR Study Groups

15.45-16.00: Welcome and Opening Remarks

16.00-17.30: SESSION 1 - Tissue Modelling and Regulation of Fibroblasts

Chairs: Adam Croft & Mary Canavan

‘Genetic and epigenetic activation of synovial fibroblasts in rheumatoid arthritis’

‘Fibroblasts as orchestrators of Immunity and Inflammation’

Sam Kemble (UK)
“Targeting fibroblasts in arthritis using engineered T cells”
Anna De Giuseppe (NO)
“Integrin a11b1 affects the invasiveness and invadopodia formation of fibroblast-like synoviocytes in arthritic hTNFtg mouse
Arjan van Caam (NL)
“Towards understanding of how T-cell and Fibroblast interaction leads to tissue
stiffness in Systemic sclerosis”

17.30-18.15: Key Note I: Fergus Shanahan (Ire) ‘The Microbiome: what is normal?’- Chair: Doug Veale

18.30 Welcome Reception – The Long Room, TCD

Friday 10th March 2023

8.30-10.00: SESSION 2 - Genetics and Epigenetics

Chairs: Florence Apparailly & Gerry Wilson

‘How population (gen)omics can identify biological mechanisms – an osteoarthritis story’

‘Cell Type Contributions to Epigenetic Dysregulation in Autoimmune Disease’

Masoumeh Mirrahimi (CHF)
“Site-specific crosstalk of HOXD13 and Hedgehog signaling in synovial fibroblasts”
Audrey Paoletti (FR)
“Liposomal AntagomiR-155-5p restores anti-inflammatory macrophages and
improves arthritis in pre-clinical models of Rheumatoid arthritis”
Astrid De Roover (BE)
“Peroxisomal Lipid Metabolism Controls H3K79 methylation, a key protective
epigenetic mechanism in Osteoarthritis”

10.00-10.30: Coffee

10.30-12.00: SESSION 3 – Metabolic Programming in Autoimmune and Inflammatory Diseases
Chairs: Rene Toes & Mariola Kurowska-Stolarska
‘IRONWARS: the battle for iron in the alveolar space’

‘Metabolic requirement of regulatory B cells’

Serena Colafrancesco (IT)
“Harnessing cell energy metabolism to suppress salivary gland inflammation in
Sjӧgren Syndrome”
Panagiota Goutakoli (GR)
“CTLA4-Ig induces tolerogenic properties of dendritic cells by altering cellular
metabolism”
Stephan Blüml (AT)
“Amino acids fuel fibroblast-like synoviocyte activation and arthritis by regulating
chemokine expression and leukocyte migration”

12.00-14.00: Lunch & Poster Session I

14.00-15.30: SESSION 4 - Innate Immunity and Cellular Repair

Chairs: Catharien Hilkens & Iain McInnes

‘Dendritic cells and SLC transporters in apoptotic cell clearance and tissue repair’

‘What does molecular imaging tell us about tissue reparation in arthritis’

Megan Hanlon (Ire)
“In depth transcriptomic analysis of myeloid populations from health to disease in Rheumatoid Arthritis”
Jack Frew (UK)
“Distinct transcriptomic profiles of peripheral blood myeloid cells predict flare upon cDMARD withdrawal in remission RA patients”
Alexandra Khmelevskaya (CHF)
“Characterization of myeloid cell subsets in the synovium of chronic inflammatory joint diseases”

15.30-16.00: Coffee

16.00-17.30: SESSION 5 – Stem Cells and  Tissue Microenvironment

Chairs: Caroline Ospelt & Ronan Mullan

‘Progenitors and fibroblasts in synovium: Two sides of the same coin?’

‘Human iPSC-Derived Cardiomyocytes for Investigation of Immunological Links Between Rheumatoid Arthritis and Cardiovascular Complications’

Eirini Stergioti (GR)
“Non-classical monocytes in Systemic Lupus Erythematosus: Molecular and functional characterization suggests differentiation to a functionally active macrophage phenotype that may promote tissue injury”
Jan Wolnik (PL)
“Modeling cardiac dysfunctions in rheumatoid arthritis using induced pluripotent stem cell-derived cardiomyocytes”
Lukács Lesinszki (HU)
“The role of the Hck tyrosine kinase in nephrotoxic nephritis”

17.30-18.15: Key note II – Luke O’Neill ‘Adventures in Immunometabolism Research’

18.30-20.00 Pizza/Beer/Wine- Knowledge Exchange

Saturday 11th March 2023

8.30-10.00: SESSION 6 – Regenerative Medicine, Cartilage and Bone

Chairs: Carl Orr & Marije Koenders

‘Biomaterials and 3D Bioprinting for Joint Regeneration’

‘Novel factors that regulate cartilage homeostasis’

Ana Escribano (BE)
“Cartilage-specific deletion of Igf1 protects against post-traumatic osteoarthritis in mice”
Tineke de Jong (NL)
“Premature aging in lymph node stromal cells of patients with rheumatoid arthritis partly restored by dasatinib treatment”
Carmen Huesa (UK)
“Differences in male and female mice in a model of early osteoarthritis”

10.00-10.30: Coffee

10.30-12.00: SESSION 7 – Adaptive Immunity and Patient Stratification

Chairs: Dianne van De Would & Costantino Pitzalis

‘Translating cellular and molecular signatures of RA risk into the Clinic’

‘Current understanding of T cells in rheumatoid arthritis (RA) – antigen specificities, repertoires and effector functions’

Matthias Jarlborg (BE)
“Influence of cigarette smoke on innate-like T cells in HLA-DR4 transgenic mice”
Carl Goetzke (DE)
“TGFβ induced immune-anergy is a hallmark of Multisystem Inflammatory
Syndrome”
Theodoros-Ioannis Papadimitriou (NL)
“Expansion of activated CD7+ cytotoxic T cells and NK cells in systemic sclerosis and prevention of fibroblast contraction through selective immunotoxinmediated depletion of these cells”

12.00-14.00: Lunch & Poster Session II

14.00-15.30: SESSION 8 – Can Nutrition and Circadian Rhythm Shape Immune Responses?

Chairs: Viviana Marzaioli & Stefano Alivernini

‘News from the gut-joint axis in rheumatoid arthritis’

‘It is just a matter of time, how circadian rhythms shape innate immunity’

Alyssa Gilmore (Ire)
“Differential mitochondrial dynamics and circadian rhythm in Rheumatoid
Arthritis and Psoriatic Arthritis circulatory monocytes”
Renée Van der Cruyssen (BE)
“A novel brain-bone axis mediates bone loss in psoriatic arthritis, without
affecting inflammation severity”
Anouk Van Mourik (NL)
“In rheumatoid arthritis, IgA autoantibodies are present in a polymeric state;
clues for a mucosal origin of the autoimmune response?”

15.30-16.00: Coffee

16.00-17.30: SESSION 9 – Cellular Niches and Immune Function

Chairs: Leonie Tamms & Sander Tas

‘Role of cellular niches in the development of RA, including the pre-clinical phase’

‘Using single cell and spatial transcriptomics to probe macrophage-niche interactions”

Aoife O’Byrne (NL)
“Human lymph node stromal cells maintain FOXP3+ regulatory T cells in a HLA-DR dependent manner”
Fabian Schälter (DR)
“Lymph node scaffold cells orchestrate onset of synovial inflammation”
DaphneDorst (NL)
“In vitro model systems to study fibroblast- immune cell interactions in systemic
sclerosis”

17.30-18.15: Key Note III – Ellen Gravallese (Harvard, USA)

‘New insights into inflammation and bone in rheumatic diseases’

Chairs: Megan Hanlon

18.15-18.30: Closing remarks and awards. A glimpse of Genoa EWRR 2024

19.30-Late: Networking Event and Farewell Dinner

Meet our Key Note Speakers for EWRR 2023

WILLIAM HANSE

Content Strategist - Hooli

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ZACHARY SCOTT

Interaction Designer - Soylent

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ROSE HAWKINS

Art Director - Globex

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JUDITH FLORES

Full Stack Developer - Initech

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BRIAN WATKINS

Web Designer - Acme

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