Scientific Program
EWRR 2023 Program Booklet
Outline of Sessions
Thursday 9th March 2023
13.30- 15.30EULAR Study Groups
15.45-16.00: Welcome and Opening Remarks
16.00-17.30: SESSION 1 - Tissue Modelling and Regulation of Fibroblasts
Chairs: Adam Croft & Mary Canavan
-
Caroline Ospelt (Ch)
- George Kollias (Gre)
‘Fibroblasts as orchestrators of Immunity and Inflammation’
• Sam Kemble (UK)
“Targeting fibroblasts in arthritis using engineered T cells”
• Anna De Giuseppe (NO)
“Integrin a11b1 affects the invasiveness and invadopodia formation of fibroblast-like synoviocytes in arthritic hTNFtg mouse
• Arjan van Caam (NL)
“Towards understanding of how T-cell and Fibroblast interaction leads to tissue
stiffness in Systemic sclerosis”
17.30-18.15: Key Note I: Fergus Shanahan (Ire) ‘The Microbiome: what is normal?’- Chair: Doug Veale
18.30 Welcome Reception – The Long Room, TCD
Friday 10th March 2023
8.30-10.00: SESSION 2 - Genetics and Epigenetics
Chairs: Florence Apparailly & Gerry Wilson
- Cindy Boer (NL)
‘How population (gen)omics can identify biological mechanisms – an osteoarthritis story’
- Esteban Ballestar (Esp)
‘Cell Type Contributions to Epigenetic Dysregulation in Autoimmune Disease’
• Masoumeh Mirrahimi (CHF)
“Site-specific crosstalk of HOXD13 and Hedgehog signaling in synovial fibroblasts”
• Audrey Paoletti (FR)
“Liposomal AntagomiR-155-5p restores anti-inflammatory macrophages and
improves arthritis in pre-clinical models of Rheumatoid arthritis”
• Astrid De Roover (BE)
“Peroxisomal Lipid Metabolism Controls H3K79 methylation, a key protective
epigenetic mechanism in Osteoarthritis”
10.00-10.30: Coffee
10.30-12.00: SESSION 3 – Metabolic Programming in Autoimmune and Inflammatory Diseases
- Suzanne Cloonan (Ire)
- Claudia Mauri (UK)
‘Metabolic requirement of regulatory B cells’
• Serena Colafrancesco (IT)
“Harnessing cell energy metabolism to suppress salivary gland inflammation in
Sjӧgren Syndrome”
• Panagiota Goutakoli (GR)
“CTLA4-Ig induces tolerogenic properties of dendritic cells by altering cellular
metabolism”
• Stephan Blüml (AT)
“Amino acids fuel fibroblast-like synoviocyte activation and arthritis by regulating
chemokine expression and leukocyte migration”
12.00-14.00: Lunch & Poster Session I
14.00-15.30: SESSION 4 - Innate Immunity and Cellular Repair
Chairs: Catharien Hilkens & Iain McInnes
- Sophia Maschalidi (Bel)
- Andreas Rammings (Ger)
‘What does molecular imaging tell us about tissue reparation in arthritis’
• Megan Hanlon (Ire)
“In depth transcriptomic analysis of myeloid populations from health to disease in Rheumatoid Arthritis”
• Jack Frew (UK)
“Distinct transcriptomic profiles of peripheral blood myeloid cells predict flare upon cDMARD withdrawal in remission RA patients”
• Alexandra Khmelevskaya (CHF)
“Characterization of myeloid cell subsets in the synovium of chronic inflammatory joint diseases”
15.30-16.00: Coffee
16.00-17.30: SESSION 5 – Stem Cells and Tissue Microenvironment
Chairs: Caroline Ospelt & Ronan Mullan
- Cosimo de Bari (UK)
- Monika Biniecka (Pol)
‘Human iPSC-Derived Cardiomyocytes for Investigation of Immunological Links Between Rheumatoid Arthritis and Cardiovascular Complications’
• Eirini Stergioti (GR)
“Non-classical monocytes in Systemic Lupus Erythematosus: Molecular and functional characterization suggests differentiation to a functionally active macrophage phenotype that may promote tissue injury”
• Jan Wolnik (PL)
“Modeling cardiac dysfunctions in rheumatoid arthritis using induced pluripotent stem cell-derived cardiomyocytes”
• Lukács Lesinszki (HU)
“The role of the Hck tyrosine kinase in nephrotoxic nephritis”
17.30-18.15: Key note II – Luke O’Neill ‘Adventures in Immunometabolism Research’
18.30-20.00 Pizza/Beer/Wine- Knowledge Exchange
Saturday 11th March 2023
8.30-10.00: SESSION 6 – Regenerative Medicine, Cartilage and Bone
Chairs: Carl Orr & Marije Koenders
- Danny Kelly (Ire)
- Rik Lories (Bel)
‘Novel factors that regulate cartilage homeostasis’
• Ana Escribano (BE)
“Cartilage-specific deletion of Igf1 protects against post-traumatic osteoarthritis in mice”
• Tineke de Jong (NL)
“Premature aging in lymph node stromal cells of patients with rheumatoid arthritis partly restored by dasatinib treatment”
• Carmen Huesa (UK)
“Differences in male and female mice in a model of early osteoarthritis”
10.00-10.30: Coffee
10.30-12.00: SESSION 7 – Adaptive Immunity and Patient Stratification
Chairs: Dianne van De Would & Costantino Pitzalis
- Andy Cope (UK)
‘Translating cellular and molecular signatures of RA risk into the Clinic’
- Vivianne Malmström (Swe)
‘Current understanding of T cells in rheumatoid arthritis (RA) – antigen specificities, repertoires and effector functions’
• Matthias Jarlborg (BE)
“Influence of cigarette smoke on innate-like T cells in HLA-DR4 transgenic mice”
• Carl Goetzke (DE)
“TGFβ induced immune-anergy is a hallmark of Multisystem Inflammatory
Syndrome”
• Theodoros-Ioannis Papadimitriou (NL)
“Expansion of activated CD7+ cytotoxic T cells and NK cells in systemic sclerosis and prevention of fibroblast contraction through selective immunotoxinmediated depletion of these cells”
12.00-14.00: Lunch & Poster Session II
14.00-15.30: SESSION 8 – Can Nutrition and Circadian Rhythm Shape Immune Responses?
Chairs: Viviana Marzaioli & Stefano Alivernini
- Mario Zaiss (Ger)
- Annie Curtis (Ire)
‘It is just a matter of time, how circadian rhythms shape innate immunity’
• Alyssa Gilmore (Ire)
“Differential mitochondrial dynamics and circadian rhythm in Rheumatoid
Arthritis and Psoriatic Arthritis circulatory monocytes”
• Renée Van der Cruyssen (BE)
“A novel brain-bone axis mediates bone loss in psoriatic arthritis, without
affecting inflammation severity”
• Anouk Van Mourik (NL)
“In rheumatoid arthritis, IgA autoantibodies are present in a polymeric state;
clues for a mucosal origin of the autoimmune response?”
15.30-16.00: Coffee
16.00-17.30: SESSION 9 – Cellular Niches and Immune Function
Chairs: Leonie Tamms & Sander Tas
- Lisa Van Baarsen (NL)
- Charlotte Scott (Bel)
‘Using single cell and spatial transcriptomics to probe macrophage-niche interactions”
• Aoife O’Byrne (NL)
“Human lymph node stromal cells maintain FOXP3+ regulatory T cells in a HLA-DR dependent manner”
• Fabian Schälter (DR)
“Lymph node scaffold cells orchestrate onset of synovial inflammation”
• DaphneDorst (NL)
“In vitro model systems to study fibroblast- immune cell interactions in systemic
sclerosis”
17.30-18.15: Key Note III – Ellen Gravallese (Harvard, USA)
‘New insights into inflammation and bone in rheumatic diseases’
Chairs: Megan Hanlon
18.15-18.30: Closing remarks and awards. A glimpse of Genoa EWRR 2024
Meet our Key Note Speakers for EWRR 2023
- Ellen M. Gravallese
- Fergus Shanahan
- Luke O'Neill